Unique IP position
InteRNA has a worldwide exclusive license and full commercial rights to patent applications covering:
- a vast collection of novel miRNA sequences that serves as product engine;
- technologies for identification and detection of miRNAs.
These patent applications cover different classes of claims ranging from product claims to method claims.
In addition, InteRNA owns several patent applications covering both method claims and use claims, protecting the use of specific miRNA mimics or antagomirs for therapeutic and diagnostic applications.
InteRNA has exclusive worldwide IP rights on the next-gen LNP formulation icw miRNAs for all disease indications.
Scientific publications
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- Bryony J. Telford, Sanaz Yahyanejad, Thijs de Gunst, Harm C. den Boer, Rogier M. Vos, Marieke Stegink, Marion T.J. van den Bosch, Mir Farshid Alemdehy, Laurens A.H. van Pinxteren, Roel Q.J. Schaapveld and Michel Janicot (2021).
Multi-modal effects of 1B3, a novel synthetic miR-193a-3p mimic, support strong potential for therapeutic intervention in oncology. Oncotarget, 2021, 12(5):422-439 - Marion T.J. van den Bosch, Sanaz Yahyanejad, Mir Farshid Alemdehy, Bryony J. Telford, Thijs M. de Gunst, Harm C. den Boer, Rogier M. Vos, Marieke Stegink, Laurens A.H. van Pinxteren, Roel Q.J. Schaapveld and Michel Janicot (2021).
Transcriptome-wide analysis reveals insight into tumor suppressor functions of 1B3, a novel synthetic miR-193a-3p mimic. Mol. Ther. Nucleic Acids, 2021, 23:1161-1171 - Vamshidhar R. Vangoor, Cristina R. Reschke, Ketharini Senthilkumar, Lieke L. van de Haar, Marina de Wit, Giuliano Giuliani, Mark H. Broekhoven, Gareth Morris, Tobias Engel, Gary P. Brennan, Ronan M. Conroy, Peter C. van Rijen, Peter H. Gosselaar, Stephanie Schorge, Roel Q.J. Schaapveld, David C. Henshall, Pierre N.E. De Graan, and R. Jeroen Pasterkamp (2019).
Antagonizing-Increased-miR-135a-Levels-at-the-Chronic-Stage-of-Experimental-TLE-Reduces-Spontaneous-Recurrent-Seizures. J. Neurosci., 2019, 39(26):5064-5079 - Eljo Y. van Battum, Marieke G. Verhagen, Vamshidhar R. Vangoor, Yuki Fujita, Alwin A.H.A. Derijck, Eoghan O’Duibhir, Giuliano Giuliani, Thijs de Gunst, Youri Adolfs, Daphne Lelieveld, David Egan, Roel Q.J. Schaapveld, Toshihide Yamashita and R. Jeroen Pasterkamp (2018).
An Image-Based miRNA Screen Identifies miRNA-135s As Regulators of CNS Axon Growth and Regeneration by Targeting Krüppel-like Factor 4. J. Neurosci., 2018, 38(3):613– 630 - Jasmijn G.M. van Kampen, Onno van Hooij, Cornelius F. Jansen, Frank P. Smit, Paula I. van Noort, Iman J. Schultz, Roel Q.J. Schaapveld, Jack A. Schalken, Gerald Verheagh (2017).
microRNA-520f reverses epithelial-to-mesenchymal transition by targeting ADAM9 and TGFBR2. Cancer Res., 2017, 77(8):2008-2017 - Negar Babae, Meriem Bourajjaj, Yijia Liu, Judy R. Van Beijnum, Francesco Cerisoli, Puthupparampil V. Scaria, Mark Verheul, Maaike P. Van Berkel, Ebel H. E. Pieters, Rick J. Van Haastert, Afrouz Yousefi, Enrico Mastrobattista, Gert Storm, Eugene Berezikov, Edwin Cuppen, Martin Woodle, Roel Q. J. Schaapveld, Gregoire P. Prevost, Arjan W. Griffioen, Paula I. Van Noort, Raymond M. Schiffelers (2014).
Systemic miRNA-7 delivery inhibits tumor angiogenesis and growth in murine xenograft glioblastoma Oncotarget, 2014, 30;5(16):6687-700 - Afrouz Yousefi, Meriem Bourajjaj, Negar Babae, Paula I. van Noort, Roel Q. J. Schaapveld, Judy R. van Beijnum, Arjan W. Griffioen, Gert Storm, Raymond M. Schiffelers, Enrico Mastrobattista (2014).
Anginex lipoplexes for delivery of anti-angiogenic siRNA. Int J Pharm, 2014, 472(1-2):175-84 - Marlon Lindenbergh-van der Plas, Sanne R. Martens-de Kemp, Michiel de Maaker, Wessel N. van Wieringen, Bauke Ylstra, Reuven Agami, Francesco Cerisoli, C. Rene Leemans, Boudewijn JM Braakhuis, and Ruud H Brakenhoff (2013).
Identification of lethal microRNAs specific for head and neck cancer. Clin Cancer Res., 2013 15;19(20):5647-57 - Jos B. Poell, Rick J. van Haastert, Thijs de Gunst, Iman J. Schultz, Willemijn M. Gommans, Mark Verheul, Francesco Cerisoli, Paula I. van Noort, Gregoire P. Prevost, Roel Q. J. Schaapveld, Edwin Cuppen (2012).
A Functional Screen Identifies Specific MicroRNAs Capable of Inhibiting Human Melanoma Cell Viability. PLoS ONE 7(8): e43569 2012 - Gommans, W.M., and Berezikov, E. (2012).
Controlling miRNA regulation in disease. Methods Mol. Biol., 2012, 822:1-18 - Gommans, W.M. and Berezikov, E. (2012).
Sample preparation for small RNA massive parallel sequencing. Methods Mol. Biol., 2012, 786:167-78 - Gommans, W.M. (2012).
A-to-I editing of microRNAs Regulating the regulators. Semin. Cell Dev. Biol., 2012, 23(3):251-7 - Poell, J.B., van Haastert, R.J., Cerisoli, F., Bolijn, A.S., Timmer, L.M., Diosdado-Calvo, B., Meijer, G.A., van Puijenbroek, .A.A, Berezikov, E., Schaapveld, R.Q., Cuppen, E. (2011).
Functional microRNA screening using a comprehensive lentiviral human microRNA expression library. BMC Genomics, 2011, 12:546
- Bryony J. Telford, Sanaz Yahyanejad, Thijs de Gunst, Harm C. den Boer, Rogier M. Vos, Marieke Stegink, Marion T.J. van den Bosch, Mir Farshid Alemdehy, Laurens A.H. van Pinxteren, Roel Q.J. Schaapveld and Michel Janicot (2021).