Edwin Cuppen, PhD – scientific co-founder InteRNA

Edwin Cuppen is professor of Human Genetics, manager Research and Education of the Division of Biomedical Genetics and director of the Center for Molecular Medicine at the University Medical Center Utrecht. Furthermore, he is director of a national large scale sequencing center, the Hartwig Medical Foundation, in Amsterdam.

He is an expert in DNA sequencing and applies next-generation sequencing for both research and diagnostic purposes. Edwin is a pioneer in personalized genomics, carrying his genome not only in his own cells, but also on his iPad.

In 2005, Edwin Cuppen received a European Young Investigators Award and in 2013, he was awarded a prestigious NWO Vici grant for dissecting the molecular mechanisms behind and functional conse-quences of structural variation in genomes. In his current work he combines experimental methods, including next-generation DNA sequencing technology and other -omics techniques, with patient cohort and cellular model systems and integrative bioinformatic approaches to understand the effects of genetic variation under normal and disease conditions like cancer and congenital disease.

He is also one of the initiators of the nationally operating Center for Personalized Cancer Treatment, for which he heads the centralized genome analysis and bioinformatic data integration efforts. This national collaboration aims for the stratification of cancer patients towards targeted treatments based on DNA measurements of the tumor. CPCT in close collaboration with the Hartwig Medical Foundation, aims to bring these developments to all cancer patients in The Netherlands in a timely and responsible manner.

Edwin Cuppen obtained his masters in molecular sciences at the Agricultural University Wageningen in 1994 (cum laude) and his PhD degree in 1999 at the Radboud University in Nijmegen in the group of Prof. Be Wieringa. During his education, he spent half a year in het Jaenish lab at the Whitehead Institute in Boston. From 1999 to 2002 he performed postdoctoral research at the Netherlands Cancer Institute in Amsterdam and the Hubrecht Institute in Utrecht, The Netherlands, in the group of Prof. Ronald Plasterk. In 2002 he became staff scientist at the Hubrecht Institute and in 2007 he was appointed professor of Genome Biology at the Biology department of the Utrecht University. In 2009 he was appointed professor of Human Genetics and head of the research section of the Medical Genetics department of the University Medical Center Utrecht, while continuing his work at the Hubrecht Institute with a split appointment. In 2015, he left the Hubrecht Insitute to transfer his research group completely to the UMC Utrecht and to become the director of the Center for Molecular Medicine.

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