Edwin Cuppen is scientific director of the Hartwig Medical Foundation, a not-for-profit organisation that aims to improve cancer care by systematic whole genome sequencing analysis of tumors. Edwin is also professor of Human Genetics at the Center for Molecular Medicine of the University Medical Center in Utrecht and invited member of the virtual national cancer research organisation Oncode Institute. After his undergraduate and PhD training at Wageningen University and Radboud University Nijmegen as a molecular geneticist, he held research and group leader positions at the Netherlands Cancer Institute and the Hubrecht Institute. His current research focuses on understanding the causes and consequences of de novo genetic variation, specifically in relation to cancer, by using systematic genomics and data integration approaches.